InhA inhibitors as potential antitubercular agents
نویسندگان
چکیده
منابع مشابه
InhA Inhibitors as Potential Antitubercular Agents (A Review)
Infectious diseases pose a potential threat and are responsible for killing more people globally than any other single cause. For six decades, antibiotics have been a bulwark against bacterial infectious diseases. This bulwark is failing due to the appearance of resistant bacterial strains. The biosynthesis pathway of fatty acids in bacteria represents a validated target for antibacterial drug ...
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Novel drugs to treat tuberculosis are required and the identification of potential targets is important. Piperidinols have been identified as potential antimycobacterial agents (MIC < 5 μg/mL), which also inhibit mycobacterial arylamine N-acetyltransferase (NAT), an enzyme essential for mycobacterial survival inside macrophages. The NAT inhibition involves a prodrug-like mechanism in which acti...
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Isoxazole (2a-l) and cyanopyridine (3a-l) derivatives have been prepared by condensing chalcones (1a-l) with hydroxylamine hydrochloride and malononitrile respectively. While compounds 1a-l have been synthesized by the reaction of p-(3’-chloro-2’-benzo(b)thiophenoylamino)-acetophenone with different aldehydes. All the compounds were screened for their antitubercular and antimicrobial activities...
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In this study, eight new ethyl {2-[3,4-diaryl-3H-thiazol-2ylidenamino]thiazol-4-yl}acetate were synthesized by reacting ethyl [2-(3-aryl(thiouredio)thiazol-4-yl]acetate and phenacyl bromides in ethanol. The solid was filtered and recrystallized from ethanol. The chemical structures of the synthesized compounds were proven by elemental analysis, IR, 1H-NMR and MS spectral data. The compounds wer...
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ژورنال
عنوان ژورنال: Oriental Journal of Chemistry
سال: 2016
ISSN: 0970-020X,2231-5039
DOI: 10.13005/ojc/320106